Evidence from animal models and observational studies support a role for vitamin K in the prevention of vascular calcification. A role for vitamin K in the prevention of vascular calcification is plausible based on the presence of vitamin K dependent proteins in vascular tissue, including matrix gla protein (MGP). 11 Department of Medicine, Queen's University, 3048C Etherington Hall, Kingston, Ontario K7L 3 V6 Canada Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario Canada.Ĭardiovascular disease, which is due in part to progressive vascular calcification, is the leading cause of death among patients with end stage kidney disease (ESKD) on dialysis.10 Department of Medicine, Tufts University, Boston, MA USA.9 Department of Medicine, University of Toronto, Toronto, Ontario Canada.8 Women's College Research Institute and Department of Endocrinology, University of Toronto, Toronto, Ontario Canada.7 Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario Canada.6 Department of Medicine, Western University, London, Ontario Canada.5 Department of Nephrology, University of Ottawa, Ottawa, Ontario Canada. 4 Department of Medicine, McMaster University, Hamilton, Ontario Canada.3 Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario Canada.2 USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA USA.1 Department of Medicine, Queen's University, 3048C Etherington Hall, Kingston, Ontario K7L 3 V6 Canada Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario Canada.
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